Harnessing Glabridin: Nature's Gift for Brighter, Healthier Skin
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Glabridin Demystified: Discovering the Power of Licorice Root Extract
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Glabridin: The Natural Elixir for Radiant Skin in Cosmetics
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Glabridin: A Natural Approach To Radiant Skin

Glabridin is a naturally occurring compound found in licorice root (Glycyrrhiza glabra). It belongs to a class of plant-based molecules called isoflavonoids, known for their antioxidant properties. These antioxidants help combat free radicals in the body, which can damage cells and contribute to various signs of aging.

The Origin of Glabridin

The plant from which licorice extract is made contains a significant amount of substance called glabridin. It’s a naturally occurring phenolic compound that falls under the flavonoid group of chemicals. The licorice plant, Glycyrrhiza glabra, is indigenous to Southern Europe and some regions of Asia. It is mostly found in India, Uzbekistan, and other countries also. It is derived from the dried rhizomes of Glycyrrhiza glabra.

How does Glabridin work on hyperpigmentation?

Glabridin-containing cosmetics are designed to cure inflammatory diseases like acne and skin flaws caused by ageing and the environment. Its brightening and anti-inflammatory properties account for its exceptional effectiveness on all skin types.

How does this powerful licorice extract work?

By preventing the melanin pigment—which gives skin its colour and is overproduced in some regions. From being produced, it aids in lessening and fading facial skin imperfections. By lowering the intensity of black spots, glabridin brightens and evens out the complexion.

Glabridin by Sunpure: Enhance Your Skincare Routine

Glabridin is a molecule well tolerated by all skin types, so it is possible to use it as a pure active ingredient to enhance its targeted action. SEPL develops five different specifications of Glabridin:  95% white powder, 90% white powder, 40% white powder & 40% yellowish to brown powder.  That can meet customers’ different needs. Numerous studies have shown that Glabridin can effectively inhibit the activity of various enzymes during melanin production, especially inhibiting tyrosinase activity. Moreover, it has other skin-care effects such as anti-inflammation, anti-oxidation and sun protection. It is a safe, mild and effective whitening active ingredient.

Glabridin Specifications
and Technical Details

  • Product Name:

    Glabridin

  • CAS Number:

    59870-68-7

  • INCI Name:

    GLYCYRRHIZA GLABRA (LICORICE) ROOT EXTRACT

  • Molecular Weight:

    324.37g/mol

  • Molecular Formula:

    C20H20O4

Glabridin Specifications
offered by Sunpure

SpecificationColour
95% BY HPLCWhite powder
90% BY HPLCWhite powder
40% BY HPLCWhite powder
40% By HPLCYellowish to Brown powder

The Process of Extracting Glabridin from Licorice Root

The Powerful Impact of Licorice Extract on Skin Imperfections

Glabridin works by inhibiting the production of melanin, the pigment responsible for skin coloration. Excess melanin can lead to dark spots and uneven skin tone. By reducing melanin production, Glabridin helps diminish and fade facial skin imperfections, such as hyperpigmentation and dark spots. This action brightens the complexion and promotes a more even skin tone.

GLYCYRRHIZA GLABRA (Glabridin): Natural Whitening Emollient

Glycyrrhiza Glabra is used as a natural whitening emollient. Its primary mechanism of action is to block the activity of the tyrosinase enzyme, which is involved in the synthesis of melanin, the pigment that gives skin its colour. Glabridin is a common ingredient in skin-lightening and brightening products because it inhibits tyrosinase, which helps to lighten and even out skin tone.
Furthermore, Glabridin has antioxidant qualities, which means it can counteract dangerous free radicals in the skin. Free radicals can oxidatively damage cells, which can result in skin damage and early ageing. Glabridin helps shield the skin from oxidative stress and preserve its youthful appearance by scavenging free radicals. Additionally, it has antioxidant properties similar to Vitamin E.

Benefits & Applications

  • Skin Brightening and Even Tone

    The most well-known cosmetic benefit of glabridin is its capacity to even out skin tone and brighten the skin. Glabridin is a strong inhibitor of tyrosinase, the enzyme that produces melanin, and it helps to lighten age spots, hyperpigmentation, and dark spots. Because of this, it's a priceless supplement to products meant to provide even and glowing skin. [1]

  • Anti-Inflammatory and Soothing Effects

    Skin irritation and inflammation are common targets for cosmetic formulations. Because of its exceptional anti-inflammatory qualities, glabridin is a great ingredient for relieving sensitive or irritated skin. Its soothing properties soften redness and discomfort, making skincare products for people with sensitive or reactive skin more tolerable. [2]

  • Antioxidant Power for Anti-Aging

    In the cosmetics industry, finding anti-aging ingredients is a never-ending quest. The antioxidant properties of glaciridin are essential for combating free radicals, a primary cause of early aging. Glabridin supports the skin's natural defenses against environmental aggressors and helps maintain a youthful appearance by shielding the skin from oxidative stress. [3]

  • Hormonal Balance in Skincare

    Glabridin's estrogenic qualities have effects on skincare in addition to the body's hormonal balance. Using glabridin-infused products can be a gentle yet effective way for postmenopausal women to support the health and vitality of their skin. [4]

  • Hyperpigmentation Management

    Melasma and other hyperpigmentation conditions can be effectively treated with glaciridin's capacity to suppress the synthesis of melanin. Glabridin's skin-brightening properties make it a common ingredient in cosmetics meant to address these issues; over time, this helps users achieve a more radiant complexion. [5]

  • Collagen Synthesis and Firmness

    The main structural protein in the skin, collagen, is essential for keeping the skin elastic and firm. According to studies, glabridin may increase the production of collagen, which would improve the texture of the skin and lessen fine lines. Because of this, it's a useful component of anti-ageing products that encourage skin firmness. [6]

  • Sun Damage Repair

    The damaging UV rays of the sun can cause skin damage and early aging. By preventing the expression of matrix metalloproteinases (MMPs), enzymes responsible for the degradation of collagen, glacidin has been investigated for its potential to treat sun damage. Glabridin may provide extra protection and assistance in healing UV-induced skin damage when added to sun care products. [7]

Scientific Studies and References on Glabridin

  1. Hakozaki, T. et al. (2002). The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer. British Journal of Dermatology, 147(1), 20-31.
  2. Kim, M. J. et al. (2015). Anti-oxidative and anti-inflammatory effects of glabridin in human keratinocytes. Immune Network, 15(4), 216-223.
  3. Kim, K. et al. (2018). Glabridin inhibits inflammation via the activation of phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) signaling. International Immunopharmacology, 65, 388-397.
  4. Armanini, D. et al. (2002). Licorice reduces serum testosterone in healthy women. Steroids, 67(10), 763-767.
  5. Yoon, G. et al. (2017). Glabridin, an isoflavan from licorice root, inhibits migration, invasion and angiogenesis, and induces apoptosis by inhibiting the nuclear factor-kappaB transcription pathway. International Journal of Oncology, 50(4), 1530-1538.
  6. Cho, S. et al. (2009). A mechanism by which licorice flavonoids increase skin elasticity: Upregulation of collagen fibrillogenesis via the PPAR-γ–Smad signal pathway. Skin Pharmacology and Physiology, 22(3), 115-125.
  7. Yoon, J. et al. (2016). Glabridin inhibits UVB-induced melanogenesis by inhibiting PI3K. International Journal of Molecular Sciences, 17(9), 1417.
  8. Wang, L., Yang, R., Yuan, B., et al. The antiviral and antimicrobial activities of licorice, a widely-used Chinese herb. Acta. Pharmac. Sin. B 5(4), 310-315 (2015).
  9. Ming, J. and Yin, A.C. Therapeutic effects of glycyrrhizic acid. Nat. Prod. Commun. 8(3), 415-418 (2013).
  10. Lee, K.J., Oh, Y.C., Cho, W.K., et al. Antioxidant and anti-inflammatory activity determination of one hundred kinds of pure chemical compounds using offline and online screening HPLC assay. Evid. Based Complement. Alternat. Med. 165457 (2015).
  11. Simmler, C., Pauli, G.F., and Chen, S.-N. Phytochemistry and biological properties of glabridin. Fitoterapia 90, 160-184 (2013).

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